Hydroxybenzomorpholine (3,4-Dihydro-2H-1,4-benzoxazin-6-ol) — CAS 26021-57-8

BASTONE supplies Hydroxybenzomorpholine (INCI: Hydroxybenzomorpholine; IUPAC: 3,4-dihydro-2H-1,4-benzoxazin-6-ol; CAS 26021-57-8) as a high-purity cosmetic intermediate for use in oxidative hair dye formulations.

Produced to 99.0% min. purity by HPLC, the material is packaged under nitrogen to protect against oxidation during storage and transit.

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Description

Hydroxybenzomorpholine is a cyclic aromatic amine that functions as a coupler in oxidative (permanent) hair dye chemistry. In the dyeing process, a coupler reacts with an oxidation base — typically a para-phenylenediamine derivative — in the presence of hydrogen peroxide to form a colored condensation product inside the hair shaft. Which coupler and oxidation base are combined determines the final shade, giving formulation chemists precise control over color output.

The EU Scientific Committee on Consumer Safety reviewed Hydroxybenzomorpholine under Colipa reference A25 and determined it safe for use at a maximum on-head concentration of 1% in oxidative hair dye formulations. BASTONE's specification reflects this regulatory context: the product is manufactured to 99.0% min. purity (HPLC-AR), with tightly controlled limits on both key process-related impurities — 2,5-dimethoxyaniline and 2-(2,5-dimethoxyphenylamino)-ethanol, each at 0.10% max. — to keep finished formulations within the safety margins regulators have evaluated.

Impurity control matters beyond regulatory compliance. 2,5-Dimethoxyaniline is a sensitization-associated precursor, and its presence in hair dye couplers at elevated levels can trigger adverse reactions and shade inconsistency in finished products. HPLC verification at release ensures each production batch delivers predictable coupler reactivity within the specified impurity envelope.

The physical form — a pink-mauve to brown powder with a melting point of 110–115°C — is well-suited to standard weighing, blending, and dissolution operations in cosmetic manufacturing. Residual solvent (water) is controlled at 0.5% max., ensuring batch-to-batch consistency in dissolution behavior when the coupler is incorporated into aqueous or aqueous-alkaline hair dye base formulations.

Specifications

Appearance

Off-white or light pink powder

Purity

≥98.0%

Factory and Activities

Hydroxybenzomorpholine (3,4-Dihydro-2H-1,4-benzoxazin-6-ol) — CAS 26021-57-8 - BASTONE Industries

Specifications

High-purity Hydroxybenzomorpholine powder packaged under nitrogen to prevent oxidation
Premium Quality: High-purity Hydroxybenzomorpholine powder packaged under nitrogen to prevent oxidation.

General Information

Parameter Detail
Chemical Name 3,4-Dihydro-2H-1,4-benzoxazin-6-ol
INCI Name Hydroxybenzomorpholine
CAS Number 26021-57-8
Molecular Formula C₈H₉NO₂
Molecular Weight 151.16 g/mol
Appearance Pink-mauve to brown powder
Application Category Oxidative hair dye coupler

Technical Specification

Parameter Specification Test Method
Purity ≥ 99.0% HPLC-AR
Assay (Titer) ≥ 98.0% Titration
UV Absorbance (λ = 203–213 nm) ABS = 0.65–0.75 UV spectrophotometry
2,5-Dimethoxyaniline ≤ 0.10% HPLC
2-(2,5-Dimethoxyphenylamino)-ethanol ≤ 0.10% HPLC
Melting Point 110–115 °C
Residual Solvent (Water) ≤ 0.5%

Full Certificate of Analysis available upon request. Test reports are traceable to individual production batches.

Applications

Oxidative (Permanent) Hair Coloring

Hydroxybenzomorpholine is formulated directly into the oxidative hair dye system. A color chemist combines the coupler with an oxidation base and a hydrogen peroxide developer; the oxidative coupling reaction occurs inside the hair shaft, producing a dye molecule too large to diffuse back out. Permanent color fastness — resistance to washing and fading — depends on the quality of the coupling reaction, which in turn depends on consistent coupler purity and impurity control at the raw material stage.

The 1% on-head concentration ceiling, confirmed by the EU SCCNFP opinion, gives formulators a well-defined working range. At BASTONE’s specified purity level, the coupler delivers predictable color yield and shade reproducibility batch-to-batch — which matters to color house chemists calibrating product lines across multiple developer strengths and oxidation base combinations.

Hair dye formulations incorporating Hydroxybenzomorpholine appear in both consumer-market permanent color kits and professional salon products. The controlled impurity profile — specifically the 0.10% max. limits on 2,5-dimethoxyaniline and its related ethanolamine — directly supports finished product compliance under EU Cosmetics Regulation (EC) No 1223/2009 Annex III, which restricts oxidative hair dye substances and their associated impurity levels.

Precise blending of hair dye couplers in a professional cosmetic manufacturing facility
Application: Precise blending of hair dye couplers in a professional cosmetic manufacturing facility.

Why Source Through BASTONE

Strict HPLC verification ensures predictable coupler reactivity and safety compliance
Quality Control: Strict HPLC verification ensures predictable coupler reactivity and safety compliance.

BASTONE operates as both manufacturer and trader of cosmetic raw materials, which means the supply chain for 3,4-Dihydro-2H-1,4-benzoxazin-6-ol sits within a single organization rather than being passed through multiple intermediaries before reaching an export desk. Each batch ships with a full Certificate of Analysis traceable to its production run — covering purity, assay, UV absorbance, impurity levels, melting point, and residual solvent, all reported against the specification table above.

For procurement teams sourcing cosmetic actives and intermediates from China, documentation quality is often the differentiator between a supplier that clears customs and regulatory review smoothly and one that generates repeated delays. BASTONE’s 10+ years of export experience means the SDS, TDS, COA, and origin documentation are prepared to the standards international buyers actually require — not produced as an afterthought when a shipment is already at port.

BASTONE’s R&D capability means technical questions get answered with substance. If a formulation team needs clarity on how a specific lot’s UV absorbance tracks against previous batches, or whether a packaging variant is feasible for a particular shipment volume, BASTONE’s technical and logistics teams can address those questions directly from production data rather than forwarding inquiries to a manufacturer they have never visited.

Sourcing & Logistics

Parameter Detail
Supply Origin China (BASTONE production)
Export Entity Zhejiang Bastone Technology Co., Ltd
Standard Packaging 5 kg net PP drum (18 L)
Inner Packaging 5 kg aluminum foil bag, nitrogen-filled
Documentation COA, SDS, TDS — batch-traceable
Trade Terms FOB, CIF, EXW — flexible per order
Sample Availability Contact BASTONE for sample requests

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